Who GeneLokr^™ is for

• Molecular biology researchers who need unbiased data from NGS, PCR, RT-qPCR and microarrays
• Biobank managers who want a stable, ambient first step before ultra-cold storage
• Clinical trial coordinators running multi-centre studies with courier transit
• Oncology and diagnostic labs collecting blood, saliva, swabs and tissue biopsies
• Genomics core facility directors who need high-molecular-weight DNA and high-RIN RNA on arrival

Why legacy preservation is failing your assays

Whether you run multi-centre clinical trials, oncology panels or high-throughput transcriptomics, traditional preservation methods introduce critical failures.

• The enzymatic degradation trap: standard buffers only try to slow down degrading enzymes. A minor temperature spike during courier transit can degrade your RNA transcriptomic profile and mRNA targets before RT-qPCR.
• The downstream inhibition barrier: heavy salt fixatives often co-purify with nucleic acids and can inhibit downstream polymerases, causing PCR dropouts, failed library preps and wasted sequencing runs.
• The logistical nightmare: heavy dry shippers and liquid nitrogen tanks drain research budgets and add operational failure points.

The GeneLokr^™ advantage: proprietary molecular precision

GeneLokr™ replaces passive chemical saturation with an advanced, proprietary sub-saturated liquid matrix, built to maximise downstream assay performance immediately after 1:1 mixing.

Key features

• Active enzyme annihilation: proprietary active molecular modifiers permanently neutralise resilient RNases and DNases, protecting total RNA and genomic DNA integrity.
• Inhibition-free purity: engineered for seamless compatibility with standard commercial spin-column and magnetic-bead extraction kits, delivering ultra-pure nucleic acids ready for sensitive enzymatic amplification.
• Zero field precipitation: stays fluid across wide temperature variations, so there are no salt crystals and 1:1 pipetting stays precise, even in cold weather.
• Cold-chain independent: no liquid nitrogen, no dry ice. RNA is stable for 5+ months and DNA for 10–12 months at 15–25°C.
• Library-ready quality: protects library complexity, reduces GC-bias and secures high DIN/RIN scores for WGS, RNA-Seq and targeted panels.

Optimised for high-sensitivity downstream workflows

• Next-generation sequencing (NGS): protects library complexity, reduces GC-bias and secures high DIN/RIN scores for WGS, RNA-Seq and targeted panels.
• PCR and RT-qPCR: eliminates trace inhibitory carryover for clean amplification curves, reproducible Ct values and reliable gene expression profiling.
• Microarrays: preserves intact transcripts and genomic integrity for high-density hybridisation and expression microarrays.
• Clinical and oncology diagnostics: secures fragile genetic material from blood, saliva, swabs and tissue biopsies without requiring immediate freezing.

How to use GeneLokr^™

1. Add your high-moisture sample to GeneLokr™ at a 1:1 ratio.
2. Close, label and ship at 15–25°C.
3. On arrival, extract straight away with your usual spin-column or magnetic-bead kit, or store at -80°C if extraction is delayed.

Stability at a glance

GeneLokr™ vs NAP buffer and commercial protectors

Comparison reflects Ruhvenile® internal assessment. RNAlater is a trademark of its owner and is named for comparison only.

Specifications

RNA stability, 15–25°C	Up to 5 months (150+ days)
DNA stability, 15–25°C	Up to 10–12 months
4°C	DNA 2–3 years; RNA up to 6 months
Frozen (-20°C to -80°C)	DNA and RNA for years; does not freeze solid
Nuclease deactivation	Permanent, irreversible
Extraction compatibility	Standard spin-column and magnetic-bead kits, with no downstream enzymatic inhibition
Mixing ratio	1:1 with high-moisture specimens
Downstream applications	NGS (WGS, RNA-Seq, targeted panels), PCR, RT-PCR, RT-qPCR, microarrays
Sequencing platforms	Illumina, PacBio, Oxford Nanopore
Quality assurance	Lot-specific CoA, technical data sheet and MSDS

Catalogue codes

Code	Pack
RUV-GLR-0.9	0.9 mL pre-filled sterilised cryotube, pack of 50
RUV-GLR-1.5	1.5 mL pre-filled cryotube, pack of 50
RUV-GLR-3.0	3.0 mL pre-filled cryotube, pack of 50
RUV-GLR-100	100 mL bottle
RUV-GLR-250	250 mL bottle
RUV-GLR-500	500 mL bottle

Trust and quality assurance

GeneLokr™ is manufactured under strict quality standards by Ruhvenile® Biomedical in New Delhi, India. Every production lot is verified for pH precision, nuclease-free material and quantitative recovery performance, and is backed by a lot-specific Certificate of Analysis (CoA), technical data sheet and MSDS.

Questions buyers ask

Do I need to keep samples in a freezer or ice chest immediately after collection?

No. GeneLokr™ provides complete ambient stabilization. Once mixed 1:1 with your sample, it instantly halts cellular metabolism and locks nucleic acids, allowing safe room-temperature transport for months without dry ice or liquid nitrogen.

Will residual GeneLokr™ matrix inhibit PCR, RT-qPCR or sequencing enzymes?

No. Unlike legacy high-salt buffers that cause polymerase inhibition, GeneLokr™ is engineered for complete compatibility with standard spin-column and magnetic-bead extraction kits, giving clean, inhibitor-free eluates.

Will GeneLokr™ cause salt crystals or precipitation in cold field weather?

No. GeneLokr™ uses an optimised, sub-saturated, highly fluid proprietary matrix designed to prevent crystal formation and ensure accurate 1:1 pipetting across diverse environmental temperatures.

What happens to the sample once it arrives back at the laboratory?

Samples are fully secure at room temperature during courier transit: RNA stays stable for up to 5 months and DNA for 10–12 months at 15–25°C. If you do not extract immediately, transfer the samples to -80°C on arrival. GeneLokr™ does not freeze solid at -20°C or -80°C.

Which downstream applications does GeneLokr™ support?

Next-generation sequencing (WGS, RNA-Seq and targeted panels), PCR, RT-PCR, RT-qPCR and microarrays. It preserves high-molecular-weight DNA and high-RIN total RNA, and suits Illumina, PacBio and Oxford Nanopore platforms.

What mixing ratio and sample types does GeneLokr™ use?

Mix 1:1 with high-moisture specimens such as blood, saliva, swabs and tissue biopsies, and with tissue from mammals, birds, fish, amphibians, plants, insects and fungi.

How does GeneLokr™ differ from standard high-salt buffers like RNAlater?

Traditional high-salt buffers rely on passive salt saturation, and salt carryover can inhibit downstream enzymes. GeneLokr™ uses an active proprietary agent that deactivates nucleases irreversibly and is engineered for inhibition-free compatibility with standard extraction kits.

What quality documents come with GeneLokr™?

Each production lot is verified for pH, nuclease-free material and quantitative recovery performance, and is backed by a lot-specific Certificate of Analysis (CoA), a technical data sheet and an MSDS.

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